Mazara del Vallo is connected to all Europe through Birgi Airport (Trapani).
 

Ryanair flights company offers very cheap flights from mains European cities.
The flights get Sicily from: Dublin, London, Liverpool, Dusseldorf, Maastricht, Munich, Memmingen, Berlin, Eindhoven, Frankfurt, Bruxelles, Oslo, Paris and Estocolmo.
 

Once at the airport Birgi, you can rent a car with leading companies of rent, if you want to move to different parts of the island.
 

Mazara is conected with the rest of Sicily along the motorway A29, and has train and autobus station.